In these two research trials we explored whether very high dose intravenous valproate or fosphenytoin might have rapid effects [within 20 minutes] on mania equivalent to the effects reported with these drugs in status epilepticus. Phrolov K, Applebaum J, Levine J, Miodovnick H, Belmaker RH. Single-dose intravenous valproate in acute mania. J Clin Psychiatry. 2004 … המשך לקרוא Can Intravenous Drugs have Rapid Effects on Mania?